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Role of B cells and antibody producing cells in chronic neuroinflammation (P17 in TRR130)
We analyze the B cell migration within the inflamed CNS parenchyma and the formation and maintenance of follicular structures in the CNS by intravital microscopy. We analyze the functional outcome of the B cell presence in the CNS, i.e. B-T interactions and their function in follicular structures and the antibody repertoire. In parallel we will translate our findings and investigate similar to the murine studies the human B cell phenotype and function in chronic neuroinflammation.

Analysis of NADPH oxidase activation in the pathogenesis of Multiple Sclerosis
We use an innovative technique based on NAD(P)H-fluorescence lifetime imaging (FLIM), which allows us to specifically detect NAD(P)H-dependent enzymatic functions in living animals. The NADPHoxidase familiy is mainly responsible for massive reactive oxygen species (ROS) production in cells and tissues. Due to the resulting massive ROS production, this contributes to neuronal dysfunction correlatively assessed by quantifying the neuronal calcium level by means of intravital FRET-FLIM.