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Molecular and Computational Neuropathology

Using genome-wide DNA methylation analysis and next-generation sequencing, we are trying to identify entity-specific molecular signatures in CNS tumors, which help to increase diagnostic accuracy, improve patient stratification and outcome prediction. Furthermore, we investigate the potential of serum-based cell-free DNA sequencing for longitudinal monitoring of brain cancer patients. A strong focus lies on the application and development of machine learning algorithms and implementation in routine diagnostic workflows.

 

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